I think I've found it.
It's all about eye movement. Try this: focus your sight to the upper left hand corner of the screen, and now move your sight down to the bottom of the screen. If you have a large enough monitor, you completely lose focus of the text and items near the upper left corner. This is problematic for tanking in that the unit frames (those things that tell you who's in your group and who you're attacking) are by default located in the upper left corner, and the action bars are located at the bottom. So if you want to make sure you're going to hit something – or even look at your keyboard for a moment – you're moving your eyes quite a bit.
Lots of us purchase these nifty mice from the local computer store. Be they a fancy new 
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